Protein structure and relationship to enzyme function

Protein Structure and Function - Biochemistry - NCBI Bookshelf

protein structure and relationship to enzyme function

Protein is a molecule that can be made of several lengths of a This makes it possible for the protein to get the structure needed for the function. If we need a globular protein with a dent on the side to make an enzyme, then. For instance, the chemical reactivity associated with these groups is essential to the function of enzymes, the proteins that catalyze specific chemical reactions in. Structure and Function Relationships of Proteins This site, called the active site of the enzyme, has amino acids that bind specifically to the substrate molecule.

The gasoline makes the reaction go faster as indicated by the charred eyebrows and singed hair of anybody trying this at home but it also gets used up. In other words, gasoline on a fire is not a catalyst. One of the best everyday examples of a catalyst is the emissions control system in your car. The main part of this system, unsurprisingly, is called a catalytic converter.

This device is a container with a series of small screens coated in precious metals platinum, rhodium, etc.

protein structure and relationship to enzyme function

These metals are catalysts for the conversion of nitric oxide a nitrogen atom bonded to an oxygen atom into nitrogen and oxygen. Figure of a catalytic converter How do catalysts work? Most catalysts including enzymes work the same basic way, because most chemical reactions including biochemical ones work the same basic way. As a good basic example, lets look at the nitric oxide reaction from the last section.

What you have is the collision of two molecules of nitric oxide that results in the breakage of nitrogen-oxygen bonds and the creation of new nitrogen-nitrogen and oxygen-oxygen bonds.

Figure showing two molecules of nitric oxide gas colliding to form a molecule of nitrogen gas and a molecule of oxygen gas If we were to dump a whole bunch of nitric oxide molecules into a normal jar with no catalytic converterand we were able to get an extreme close-up of what was going on at the molecular level, we would see millions of N-O molecules spinning and tumbling in space, smashing into each other and ricocheting off the walls of the jar at incredible speeds.

protein structure and relationship to enzyme function

Very, very few nitrogen or oxygen molecules would be created, whereas most ofthe nitric oxide molecules would just bounce off of each other. Why the nitric oxide molecules bounce off each other: You also know that if you try and align one pole of a magnet with the same pole of the other, the magnets will repel. Nitrogen and oxygen atoms are like magnets in this sense. Figure showing magnets attracting and repelling and a figure a nitrogen and oxygen atom attracting and repelling.

Enzyme structure and function

The first rule is that there is a mutual attraction between red magnets and blue magnets. This means that if you stick the north pole of a red magnet to the south pole of a blue magnet, they will stick together, just like you would expect with two magnets.

The second rule is that there is a stronger mutual attraction between magnets of the same color: What this means is that a red magnet will prefer to stick to another red magnet, and a blue magnet will prefer to stick to another blue magnet, if given the choice. So those are the rules about how our magnets behave.

protein structure and relationship to enzyme function

If the poles of the colliding magnets are lined up in the correct way, so that the north pole of one red magnet is contacting the south pole of the other red magnet, with the same happening for the blue magnets, what would happen?

But only if the alignment is correct! Figure of nitrogen and oxygen atoms colliding then bonding. This magnet thought experiment is a good approximation of what happens with real-life molecules like nitric oxide.

What is the relationship between a protein's structure and its ability to function?

But the alignment is key--nothing will happen without it. This is where catalysts come in. They help with alignment.

The odds favor nothing happening.

protein structure and relationship to enzyme function

This is what happens with nitric oxide molecules in a jar, when no catalyst is present. Figure of nitric oxide molecules in a jar unable to correctly align. But now imagine that we add an extremely motivated and conscientious magic gnome to the inside of our jar, with the instructions that he is to grab a red-blue in each one of his hands, align them in the right way, and then smash them together.

Adding this helpful gnome assistant will increase the rate at which red-reds and blue-blues are made, because achieving the right alignment is no longer a matter of random chance. Figure of nitric oxide molecules in a jar correctly aligning in the presence of a catalyst.

Enzyme structure and function (article) | Khan Academy

Catalysts are the real-life versions of our imaginary magic gnomes. A platinum screen sits inside a catalytic converter attracting nitric oxide molecules to it and aligning them in just the right way, so that when they collide, the N and O switch places, and nitrogen gas and oxygen gas are created.

Catalysts make reactions fast by aligning reactants so that successful reactions are more likely! Enzymes are biological catalysts Enzymes are the catalysts involved in biological chemical reactions.

Why enzymes are so important The big reason enzymes are important to life is because cellular energy is a precious resource. This increase in the total number of collisions per second would increase, just as a matter of probability, the number of correctly aligned collisions too. So, in the end, shaking the jar harder much harder, perhaps would result in an increase in the speed of red-red and blue-blue production too, just like adding a gnome and keeping the shaking of the jar the same.

Figure of nitric oxide molecules in a shaking jar correctly and incorrectly aligning. The function of a protein is directly dependent on its threedimensional structure Figure 3. Remarkably, proteins spontaneously fold up into three-dimensional structures that are determined by the sequence of amino acids in the protein polymer.

Thus, proteins are the embodiment of the transition from the one-dimensional world of sequences to the three-dimensional world of molecules capable of diverse activities. Proteins contain a wide range of functional groups. These functional groups include alcohols, thiols, thioethers, carboxylic acids, carboxamides, and a variety of basic groups.

When combined in various sequences, this array of functional groups accounts for the broad spectrum of protein function. For instance, the chemical reactivity associated with these groups is essential to the function of enzymes, the proteins that catalyze specific chemical reactions in biological systems see Chapters 8— Proteins can interact with one another and with other biological macromolecules to form complex assemblies.

The proteins within these assemblies can act synergistically to generate capabilities not afforded by the individual component proteins Figure 3. These assemblies include macro-molecular machines that carry out the accurate replication of DNAthe transmission of signals within cells, and many other essential processes.

protein structure and relationship to enzyme function